Synthesis, characterization, and pharmacological evaluation of some metal complexes of quercetin as P-gp inhibitors

Abstract Background Six different metal complexes of quercetin (Cu, Zn, Co, Vd, Mo, Ni) were synthesized, purified, and characterized by their physical spectral (UV, IR) data. They evaluated for P-gp (permeability glycoprotein) inhibitory activity in vitro everted sac method rats. The apparent permeability atorvastatin (P-gp substrate) from the rat intestine was determined control, standard (verapamil), groups treated with quercetin-metal complexes. drug contents analyzed validated RP-HPLC using a mixture acetonitrile water (60:40 v/v) adjusted to pH 2.8 phosphate buffer as mobile phase. Results In studies revealed that across small is much affected treatment Cu/Co/Ni quercetin. mean ± SD decreased after pre-treatment these Conclusions could inhibit increase absorption. Hence, they be considered inhibitors.